Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monomethyl Fumarate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 known ✓ | Q14145 | 1/20 | 0.56 |
| ▸ | HCAR2 | Q8TDS4 | 11/20 | 0.74 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | GFPT1 | Q06210 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Monomethyl Fumarate SCHEMBL11129720 | 0.86 | HCAR2 (0.81) | HCAR2KEAP1NFE2L2ALDH1A1KDM4E | |
| Maleic Acid SCHEMBL2833047 | 0.86 | HCAR2 (0.61) | HCAR2ALDH1A1TDP1ALOX15RECQL | |
| Fumaric Acid SCHEMBL11884545 | 0.86 | HCAR2 (0.61) | HCAR2ALDH1A1TDP1ALOX15RECQL | |
| Fumaric Acid SCHEMBL6291284 | 0.86 | HCAR2 (0.61) | HCAR2ALDH1A1TDP1ALOX15RECQL | |
| Monomethyl Fumarate SCHEMBL25280962 | 0.86 | HCAR2 (1.00) | HCAR2KEAP1NFE2L2ALDH1A1KDM4E | |
| Dimethyl Fumarate SCHEMBL15573963 | 0.86 | HCAR2 (1.00) | HCAR2KEAP1NFE2L2ALDH1A1KDM4E | |
| Dimethyl Maleate SCHEMBL6896824 | 0.86 | HCAR2 (1.00) | HCAR2KEAP1NFE2L2ALDH1A1KDM4E | |
| Monomethyl Fumarate SCHEMBL60132 | 0.86 | — | — | |
| Dimethyl Fumarate SCHEMBL15573962 | 0.86 | HCAR2 (1.00) | HCAR2KEAP1NFE2L2ALDH1A1KDM4E | |
| Monomethyl Fumarate SCHEMBL126468 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250206881-A1 | MODIFIED LYSINE-BASED POLYMER AND COMPOSITIONS COMPRISING THE SAME | BASF SE (DE) | 2025-06-26 | — | — | US | disclosed |
| EP-4504820-A1 | MODIFIED LYSINE-BASED POLYMER AND COMPOSITIONS COMPRISING THE SAME | BASF SE (DE) | 2025-02-12 | — | — | EP | disclosed |
| CN-119032120-A | Modified lysine-based polymers and compositions containing the same | 巴斯夫欧洲公司 | 2024-11-26 | — | — | CN | disclosed |
| WO-2023193713-A1 | MODIFIED LYSINE-BASED POLYMER AND COMPOSITIONS COMPRISING THE SAME | BASF SE (DE) | 2023-10-12 | — | — | WO | disclosed |
| US-6228559-B1 | PHOTOSENSITVE LAYER ABD SILICONE RUBBER ON SUPPORT | FUJI PHOTO FILM CO., LTD. (JP) | 2001-05-08 | — | — | US | disclosed |