Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 7/20 | 0.61 |
| ▸ | TSHR | P16473 | 5/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.53 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.38 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6291284 | 1.00 | HCAR2 (0.61) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL11884545 | 1.00 | HCAR2 (0.61) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL27742359 | 0.97 | HCAR2 (0.58) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL19900431 | 0.95 | HCAR2 (0.56) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Ether SCHEMBL10818100 | 0.88 | HCAR2 (0.50) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Crotonic Acid SCHEMBL4822259 | 0.87 | HCAR2 (0.48) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Crotonic Acid SCHEMBL4822268 | 0.87 | HCAR2 (0.48) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Monomethyl Fumarate SCHEMBL7848423 | 0.86 | HCAR2 (0.74) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Ethyl Fumarate SCHEMBL7847245 | 0.86 | HCAR2 (0.87) | HCAR2ALDH1A1LMNANPSR1 | |
| Sorbic Acid SCHEMBL6851012 | 0.81 | HCAR2 (0.43) | HCAR2TSHRTP53EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230414462-A1 | UNIT-DOSE ORAL CARE COMPOSITIONS COMPRISING FLUORIDE | THE PROCTER & GAMBLE COMPANY | 2023-12-28 | — | — | US | claimed |
| WO-2023196214-A1 | UNIT-DOSE ORAL CARE COMPOSITIONS COMPRISING FLUORIDE | THE PROCTER & GAMBLE COMPANY (US) | 2023-10-12 | — | — | WO | claimed |
| EP-3793515-A1 | FOAMING ORAL CARE COMPOSITIONS | The Procter & Gamble Company (US) | 2021-03-24 | — | — | EP | claimed |
| EP-3793692-A1 | ORAL CARE COMPOSITIONS COMPRISING METAL IONS | The Procter & Gamble Company (US) | 2021-03-24 | — | — | EP | claimed |
| EP-3793507-A1 | ORAL CARE COMPOSITIONS COMPRISING FLUORIDE IONS | The Procter & Gamble Company (US) | 2021-03-24 | — | — | EP | claimed |
| US-20190343733-A1 | Oral Care Compositions Comprising Metal Ions | THE PROCTER & GAMBLE COMPANY | 2019-11-14 | — | — | US | claimed |
| US-20190343737-A1 | Oral Care Compositions Comprising Fluoride Ions | THE PROCTER & GAMBLE COMPANY | 2019-11-14 | — | — | US | claimed |
| US-20190343735-A1 | Foaming Oral Care Compositions | THE PROCTER & GAMBLE COMPANY | 2019-11-14 | — | — | US | claimed |
| CN-105504182-B | Nanoscale Pickering emulsion type fracturing fluid and preparation method thereof | 中国石油天然气股份有限公司 | 2018-01-02 | — | — | CN | claimed |
| CN-103641747-B | A kind of stearyl alcohol polyoxyethylene (5) ether sodium sulfosuccinic diester ultrasonic-microwave synthesis method | JIANGNAN UNIVERSITY (CN) | 2015-11-25 | — | — | CN | claimed |
| EP-2928969-A1 | CROSS-LINKABLE COMPOSITIONS BASED ON DIANHYDROHEXITOL COMPOUNDS | Roquette Frères (FR) | 2015-10-14 | — | — | EP | claimed |
| WO-2014087112-A1 | CROSS-LINKABLE COMPOSITIONS BASED ON DIANHYDROHEXITOL COMPOUNDS | ROQUETTE FRERES (FR) | 2014-06-12 | — | — | WO | claimed |
| CN-103641747-A | Method for ultrasound-microwave synthesis of stearyl alcohol polyoxyethylene (5) ether succinic acid diester sodium sulfonate | UNIV JIANGNAN | 2014-03-19 | — | — | CN | claimed |
| CN-101830896-B | Organic acid salt of optical isomer of penehyclidine | YUNNAN LVYE BIOLOG MEDICINE CO LTD | 2013-05-15 | — | — | CN | claimed |
| EP-1608601-B1 | CEMENT ADDITIVE | CONSTR RES & TECH GMBH (DE) | 2012-09-19 | — | — | EP | claimed |
| CN-101830896-A | Organic acid salt of optical isomer of penehyclidine | YUNNAN LVYE BIOLOG MEDICINE CO LTD | 2010-09-15 | — | — | CN | claimed |
| US-7482405-B2 | Cement additive | CONSTRUCTION RESEARCH & TECHNOLOGY GMBH (DE) | 2009-01-27 | — | — | US | claimed |
| US-20060247402-A1 | Cement additive | CONSTRUCTION RESEARCH & TECHNOLOGY GMBH (DE) | 2006-11-02 | — | — | US | claimed |
| EP-1608601-A1 | CEMENT ADDITIVE | Construction Research & Technology GmbH (DE) | 2005-12-28 | — | — | EP | claimed |
| WO-2004087602-A1 | CEMENT ADDITIVE | CONSTRUCTION RESEARCH & TECHNOLOGY GMBH (DE) | 2004-10-14 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190343733-A1 | Oral Care Compositions Comprising Metal Ions | SLC39A7, SLC30A7, SLC39A3 | HCAR2 2873/4885TSHR 3609/4885TP53 1880/4885 |
| US-20190343735-A1 | Foaming Oral Care Compositions | FOS, STOM, UGCG | HCAR2 3641/4885TSHR 2537/4885TP53 1932/4885 |
| US-20190343737-A1 | Oral Care Compositions Comprising Fluoride Ions | F9, CACNA1C, FLNA | HCAR2 2497/4885TSHR 1315/4885TP53 2087/4885 |
| US-20230414462-A1 | UNIT-DOSE ORAL CARE COMPOSITIONS COMPRISING FLUORIDE | F9, PEF1, NAF1 | HCAR2 4549/4885TSHR 278/4885TP53 2827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.