Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NCF1 | P14598 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | SCN1A | P35498 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8673288 | 0.86 | MEN1 (0.48) | MEN1KMT2ANCF1KDM4EABCB11 | |
| SCHEMBL31587740 | 0.84 | LMNA (0.56) | MEN1KMT2AKDM4EABCB11LMNA | |
| SCHEMBL8412379 | 0.82 | AGTR1 (0.48) | MEN1KMT2ANCF1KDM4EABCB11 | |
| SCHEMBL21166292 | 0.80 | AGTR1 (0.47) | MEN1KMT2ANCF1KDM4ELMNA | |
| SCHEMBL19732877 | 0.80 | AGTR1 (0.47) | MEN1KMT2ANCF1KDM4ELMNA | |
| SCHEMBL951984 | 0.80 | LMNA (0.55) | MEN1KMT2AKDM4ELMNA | |
| SCHEMBL8410524 | 0.79 | MEN1 (0.43) | MEN1KMT2AKDM4EABCB11LMNA | |
| SCHEMBL8671748 | 0.78 | MEN1 (0.51) | MEN1KMT2AKDM4EABCB11LMNA | |
| SCHEMBL9179529 | 0.77 | MEN1 (0.53) | MEN1KMT2AKDM4EABCB11LMNA | |
| SCHEMBL7838473 | 0.77 | NR1H4 (0.49) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0498723-B1 | Nitrogen containing bicycle compounds, method for their preparation, their use as pharmaceutical and compositions containing them | AVENTIS PHARMA SA (FR) | 2001-09-19 | — | — | EP | disclosed |
| EP-0498723-A1 | Nitrogen containing bicycle compounds, method for their preparation, their use as pharmaceutical and compositions containing them | ROUSSEL UCLAF (FR) | 1992-08-12 | — | — | EP | disclosed |