Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | APAF1 | O14727 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 4/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 5/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 3/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30215698 | 0.87 | HTR7 (0.50) | HPGDCASP3GAAHTR7HTR1A | |
| SCHEMBL185755 | 0.87 | HTR7 (0.50) | HPGDCASP3GAAHTR7HTR1A | |
| SCHEMBL1260843 | 0.84 | KMT2A (0.60) | ADRA1DADRA1AADRA1BKMT2AALDH1A1 | |
| SCHEMBL14139497 | 0.77 | KMT2A (0.49) | KMT2AALDH1A1MAPTAPAF1MEN1 | |
| SCHEMBL8224822 | 0.76 | POLB (0.59) | ADRA1DADRA1AADRA1BKMT2AMAPT | |
| SCHEMBL4433161 | 0.76 | KMT2A (0.47) | KMT2AALDH1A1MAPTAPAF1MEN1 | |
| SCHEMBL14139369 | 0.74 | KMT2A (0.47) | KMT2AALDH1A1MAPTAPAF1MEN1 | |
| SCHEMBL10753574 | 0.73 | MAPT (0.44) | KMT2AALDH1A1MAPTHPGDCASP3 | |
| SCHEMBL11567064 | 0.73 | ADRA1D (0.47) | ADRA1DADRA1AADRA1BALDH1A1MAPT | |
| SCHEMBL11401803 | 0.73 | CASP3 (0.54) | ALDH1A1MAPTCASP3PKMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089981-A1 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS. | Elan Pharmaceuticals, Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067220-A1 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | ELAN PHARMACEUTICALS, INC. (US) | 1999-12-29 | — | — | WO | disclosed |