Sugi Predict

Sugi Predict / Compounds / SCHEMBL7849003

SCHEMBL7849003

SCHEMBL7849003

O=C(O)c1c(N2CC=CN2)ccc2ccccc12

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 6/20 0.42
▸ ALDH1A1 P00352 4/20 0.42
▸ HSD17B10 Q99714 4/20 0.42
▸ HPGD P15428 4/20 0.42
▸ GLA P06280 3/20 0.42
▸ MEN1 O00255 2/20 0.42
▸ KMT2A Q03164 2/20 0.42
▸ CYP1A2 P05177 1/20 0.42
▸ CYP2C19 P33261 1/20 0.42
▸ MAPT P10636 2/20 0.39
▸ GAA P10253 1/20 0.39
▸ RCE1 Q9Y256 1/20 0.39
▸ METAP2 P50579 2/20 0.38
▸ METAP1 P53582 1/20 0.38
▸ WDR5 P61964 1/20 0.37
▸ LDHA P00338 1/20 0.36
▸ USP2 O75604 1/20 0.36
▸ NR4A1 P22736 1/20 0.36
▸ NR4A2 P43354 1/20 0.36
▸ NR4A3 Q92570 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6627987 0.76 HSD17B10 (0.46) KDM4EALDH1A1HSD17B10HPGDMEN1
Water SCHEMBL8971546 0.67 ALDH1A1 (0.59) KDM4EALDH1A1HSD17B10HPGDGLA
Water SCHEMBL2359149 0.67 WDR5 (0.66) KDM4EALDH1A1HSD17B10HPGDGLA
SCHEMBL11054895 0.67 KDM4E (0.42) KDM4EALDH1A1HSD17B10HPGDGLA
SCHEMBL4958730 0.67 ALDH1A1 (0.59) KDM4EALDH1A1HSD17B10HPGDGLA
SCHEMBL344095 0.67 HSD17B10 (0.59) KDM4EALDH1A1HSD17B10HPGDGLA
SCHEMBL1661024 0.66 HSD17B10 (0.63) KDM4EALDH1A1HSD17B10HPGDGLA
Water SCHEMBL9498588 0.65 ABCG2 (0.57) KDM4EALDH1A1HSD17B10HPGDGLA
SCHEMBL33850 0.65 WDR5 (0.68) KDM4EALDH1A1HSD17B10HPGDGLA
SCHEMBL1809752 0.65 HSD17B10 (0.61) KDM4EALDH1A1HSD17B10HPGDGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20010012905-A1 Synthesis of pyrazolinylnaphthalic acid derivatives EMAGIN CORPORATION 2001-08-09 — — US claimed
US-6288232-B2 REACTION OF ACETYLNAPHTHALIC ANHYDRIDE AND ALDEHYDE IN THE PRESENCE OF AQUEOUS BASE AND BOILING IN THE PRESENCE OF ANILINE COMPOUND EMAGIN CORPORATION 2001-09-11 — — US disclosed
US-6288232-B2 REACTION OF ACETYLNAPHTHALIC ANHYDRIDE AND ALDEHYDE IN THE PRESENCE OF AQUEOUS BASE AND BOILING IN THE PRESENCE OF ANILINE COMPOUND EMAGIN CORPORATION 2001-09-11 — — US disclosed
US-6288232-B2 REACTION OF ACETYLNAPHTHALIC ANHYDRIDE AND ALDEHYDE IN THE PRESENCE OF AQUEOUS BASE AND BOILING IN THE PRESENCE OF ANILINE COMPOUND EMAGIN CORPORATION 2001-09-11 — — US disclosed
US-20010012905-A1 Synthesis of pyrazolinylnaphthalic acid derivatives EMAGIN CORPORATION 2001-08-09 — — US disclosed
US-20010012905-A1 Synthesis of pyrazolinylnaphthalic acid derivatives EMAGIN CORPORATION 2001-08-09 — — US disclosed
US-20010012905-A1 Synthesis of pyrazolinylnaphthalic acid derivatives EMAGIN CORPORATION 2001-08-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010012905-A1 Synthesis of pyrazolinylnaphthalic acid derivatives AHR, NAT1, ARSA KDM4E 3163/4885ALDH1A1 134/4885HSD17B10 2036/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.