SCHEMBL7849424

SCHEMBL7849424

CCCOc1c(Cl)cnc(F)c1Cl

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.33
MEN1 O00255 1/20 0.33
ALDH1A1 P00352 1/20 0.33
MAPT P10636 1/20 0.33
HPGD P15428 1/20 0.33
HTT P42858 1/20 0.33
CSNK2A1 P68400 2/20 0.33
ENPP1 P22413 1/20 0.32
NPBWR1 P48145 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7849743 0.85 CHUK (0.38) ALDH1A1MAPTHPGDHTTNPBWR1
SCHEMBL7850605 0.79 ALDH1A1 (0.34) KMT2AMEN1ALDH1A1
SCHEMBL7852618 0.73 NPBWR1 (0.31) NPBWR1
SCHEMBL11312550 0.69 KMT2A (0.36) KMT2AMEN1ALDH1A1MAPTHPGD
SCHEMBL11317256 0.68 ALDH1A1 (0.36) KMT2AMEN1ALDH1A1MAPTHPGD
SCHEMBL10264570 0.67 MKNK1 (0.37) KMT2AMEN1ALDH1A1MAPTHPGD
SCHEMBL9047154 0.67 NPC1 (0.35) HTT
SCHEMBL12874582 0.66 PLAU (0.46) KMT2AMEN1HPGDHTT
SCHEMBL7853732 0.65 NOTUM (0.30)
SCHEMBL31289893 0.65 NOTUM (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0717743-B1 N-ARYL 1,2,4]TRIAZOLO 1,5-a]PYRIDINE-2-SULFONAMIDE HERBICIDES DOW AGROSCIENCES LLC (US) 2001-11-14 EP disclosed
EP-0972774-A2 2-Benzylthio-8-amino(1,2,4)triazolo(1,5-pyridines Dow AgroSciences LLC (US) 2000-01-19 EP disclosed
US-5700940-A FOR PRE- OR POSTEMERGENCE SPRAYING OF PLANTS OR SOILS DOWELANCO (US) 1997-12-23 US disclosed
US-5614469-A N-pyridinyl[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide herbicides DOWELANCO (US) 1997-03-25 US disclosed
US-5571775-A EFFECTIVE ON A BROAD SPECTRUM OF VEGETATION AT LOW APPLICATION RATES DOWELANCO (US) 1996-11-05 US disclosed
EP-0717743-A1 N-ARYL 1,2,4]TRIAZOLO 1,5-a]PYRIDINE-2-SULFONAMIDE HERBICIDES DOWELANCO (US) 1996-06-26 EP disclosed
WO-1996001826-A1 N-ARYL[1,2,4]TRIAZOLO[1,5-a]PYRIDINE-2-SULFONAMIDE HERBICIDES DOWELANCO (US) 1996-01-25 WO disclosed