Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCND2 | P30279 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9043636 | 0.87 | CYP2D6 (0.36) | RAB9ASMN1; SMN2THRATHRBCYP2D6 | |
| SCHEMBL8566574 | 0.71 | CCNB2 (0.35) | NPC1RAB9ASMN1; SMN2HSD17B10THRA | |
| SCHEMBL2394227 | 0.71 | — | — | |
| SCHEMBL9683149 | 0.71 | LTA4H (0.39) | THRATHRBCYP2D6CYP3A4CYP19A1 | |
| SCHEMBL8405077 | 0.71 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2HSD17B10THRA | |
| SCHEMBL9683985 | 0.71 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2HSD17B10THRA | |
| SCHEMBL10692851 | 0.67 | LTA4H (0.46) | RAB9ATHRATHRBCYP2D6CYP3A4 | |
| SCHEMBL9793563 | 0.67 | TSHR (0.39) | SMN1; SMN2THRATHRBCYP3A4HTT | |
| SCHEMBL7849424 | 0.67 | KMT2A (0.33) | HTT | |
| SCHEMBL18655825 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723545-A1 | QUINOLIZINONE TYPE COMPOUNDS | ABBOTT LABORATORIES (US) | 1996-07-31 | — | — | EP | disclosed |