Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PSMD10 | O75832 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5550702 | 0.93 | ALDH1A1 (0.48) | ALDH1A1HSD17B10NPSR1HPGDKMT2A | |
| SCHEMBL9162906 | 0.82 | PSMD10 (0.40) | ALDH1A1KMT2AMEN1GAAPSMD10 | |
| SCHEMBL22284359 | 0.78 | GPR119 (0.49) | KMT2AMEN1GPR119MMP13TP53 | |
| SCHEMBL9703324 | 0.77 | MEN1 (0.51) | KMT2AMEN1SMN1; SMN2GPR119MMP13 | |
| SCHEMBL8651411 | 0.76 | GPR119 (0.67) | KMT2AMEN1GPR119MMP13 | |
| SCHEMBL31683631 | 0.76 | GPR119 (0.67) | KMT2AMEN1GPR119MMP13 | |
| SCHEMBL16759629 | 0.75 | ALDH1A1 (0.55) | ALDH1A1HSD17B10NPSR1HPGDKMT2A | |
| SCHEMBL22032226 | 0.75 | GPR119 (0.68) | KMT2AMEN1GPR119MMP13 | |
| SCHEMBL31746376 | 0.75 | GPR119 (0.68) | KMT2AMEN1GPR119MMP13 | |
| SCHEMBL30750650 | 0.75 | GPR119 (0.51) | KMT2AMEN1GPR119MMP13TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1154774-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AstraZeneca AB (SE) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047212-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2000-08-17 | — | — | WO | disclosed |