Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MTTP | P55157 | 9/20 | 0.40 |
| ▸ | APOB | P04114 | 3/20 | 0.40 |
| ▸ | MMP9 | P14780 | 5/20 | 0.40 |
| ▸ | MMP2 | P08253 | 4/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 2/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL786257 | 1.00 | GAA (0.41) | GAASMN1; SMN2POLBMTTPAPOB | |
| SCHEMBL14735725 | 0.89 | MTTP (0.43) | GAASMN1; SMN2POLBMTTPAPOB | |
| SCHEMBL14735786 | 0.89 | MTTP (0.43) | GAASMN1; SMN2POLBMTTPAPOB | |
| Usistapide SCHEMBL785351 | 0.88 | NPY2R (0.47) | GAAPOLBMTTPAPOBMMP9 | |
| SCHEMBL785583 | 0.82 | MTTP (0.49) | GAASMN1; SMN2MTTPAPOBALDH1A1 | |
| SCHEMBL785584 | 0.82 | MTTP (0.49) | GAASMN1; SMN2MTTPAPOBALDH1A1 | |
| SCHEMBL786048 | 0.82 | MTTP (0.49) | GAASMN1; SMN2MTTPAPOBALDH1A1 | |
| Usistapide SCHEMBL29376869 | 0.69 | NPY2R (0.62) | MTTPAPOB | |
| Usistapide SCHEMBL803532 | 0.69 | NPY2R (0.62) | MTTPAPOB | |
| Usistapide SCHEMBL785394 | 0.69 | NPY2R (0.62) | MTTPAPOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071660-A1 | RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'(TRIFLUOROMETHYL)-2- BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-22 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071660-A1 | RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'(TRIFLUOROMETHYL)-2- BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE | MTTP, CETP, LIPC | GAA 1218/4885SMN1; SMN2 3780/4885POLB 2334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.