Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 13/20 | 0.49 |
| ▸ | APOB | P04114 | 9/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | FPR2 | P25090 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL785584 | 1.00 | MTTP (0.49) | MTTPAPOBKDM4EGAAALDH1A1 | |
| SCHEMBL786048 | 1.00 | MTTP (0.49) | MTTPAPOBKDM4EGAAALDH1A1 | |
| SCHEMBL5153696 | 0.84 | APOB (0.52) | MTTPAPOBKDM4EGAAALDH1A1 | |
| SCHEMBL6700839 | 0.82 | NAMPT (0.58) | MTTPAPOBKDM4EGAAMAPT | |
| SCHEMBL2589154 | 0.82 | HIF1A (0.59) | MTTPAPOBKDM4EGAAALDH1A1 | |
| SCHEMBL786257 | 0.82 | GAA (0.41) | MTTPAPOBKDM4EGAAALDH1A1 | |
| SCHEMBL785011 | 0.82 | GAA (0.41) | MTTPAPOBKDM4EGAAALDH1A1 | |
| Acetic Acid SCHEMBL2586104 | 0.81 | APOB (0.55) | MTTPAPOB | |
| SCHEMBL904380 | 0.80 | MTTP (0.52) | MTTPAPOBFPR2 | |
| SCHEMBL904381 | 0.80 | MTTP (0.52) | MTTPAPOBFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071660-A1 | RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'(TRIFLUOROMETHYL)-2- BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-22 | — | — | US | claimed |
| EP-2435406-A1 | RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'-(TRIFLUOROMETHYL)-2-BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE | Janssen Pharmaceutica, N.V. (BE) | 2012-04-04 | — | — | EP | disclosed |
| US-20120071660-A1 | RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'(TRIFLUOROMETHYL)-2- BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-22 | — | — | US | disclosed |
| US-20120071660-A1 | RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'(TRIFLUOROMETHYL)-2- BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071660-A1 | RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'(TRIFLUOROMETHYL)-2- BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE | MTTP, CETP, LIPC | MTTP 1/4885APOB 48/4885KDM4E 635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.