Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20389744 | 0.94 | HRH3 (0.52) | HRH3ALDH1A1TSHRMAPTHRH1 | |
| SCHEMBL7850426 | 0.87 | HRH3 (0.67) | HRH3ALDH1A1TSHRMAPTHRH1 | |
| SCHEMBL27528159 | 0.85 | HRH3 (0.71) | HRH3ALDH1A1TSHRMAPTCYP1A2 | |
| SCHEMBL690245 | 0.85 | ALDH1A1 (0.45) | HRH3ALDH1A1TSHRMAPTCYP1A2 | |
| SCHEMBL19841298 | 0.82 | ALDH1A1 (0.42) | HRH3ALDH1A1TSHRMAPTCYP1A2 | |
| Iodide SCHEMBL8913931 | 0.80 | HRH3 (0.52) | HRH3 | |
| SCHEMBL6678765 | 0.80 | HRH3 (0.62) | HRH3ALDH1A1TSHRMAPTHRH1 | |
| SCHEMBL22271407 | 0.80 | HRH3 (0.55) | HRH3ALDH1A1TSHRMAPTCYP1A2 | |
| SCHEMBL27341646 | 0.79 | SIGMAR1 (0.45) | HRH3ALDH1A1SIGMAR1 | |
| SCHEMBL8966776 | 0.78 | HRH3 (0.43) | HRH3ALDH1A1TSHRHRH1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468434-B1 | Novel piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis | MERRELL DOW PHARMA (US) | 1996-02-28 | — | — | EP | disclosed |
| US-5348964-A | Anticholesterol agents or fungicides | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-09-20 | — | — | US | disclosed |
| CN-1058399-A | New piperidine ether and thioether as cholesteral biosynthesis inhibitor | MERRELL DOW PHARMA (US) | 1992-02-05 | — | — | CN | disclosed |
| EP-0468434-A1 | Novel piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-29 | — | — | EP | disclosed |