Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 6/20 | 0.43 |
| ▸ | EDNRB | P24530 | 5/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 7/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | DHPS | P49366 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | FLT1 | P17948 | 1/20 | 0.31 |
| ▸ | FLT4 | P35916 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | TEK | Q02763 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4426889 | 0.80 | EDNRA (0.49) | EDNRAEDNRBDHPSTEK | |
| SCHEMBL7850652 | 0.79 | EDNRA (0.47) | EDNRAEDNRBKDRERBB2DHPS | |
| SCHEMBL4432925 | 0.75 | EDNRA (0.65) | EDNRAEDNRB | |
| SCHEMBL4434185 | 0.73 | DHPS (0.42) | EDNRAEDNRBERBB2DHPSTEK | |
| SCHEMBL5097996 | 0.73 | EDNRB (0.56) | EDNRAEDNRB | |
| SCHEMBL5632102 | 0.72 | EDNRB (0.77) | EDNRAEDNRB | |
| Alcohol SCHEMBL8637347 | 0.71 | EDNRB (0.40) | EDNRAEDNRBRETERBB2DHPS | |
| SCHEMBL16762457 | 0.70 | ALDH1A1 (0.45) | — | |
| SCHEMBL7851914 | 0.68 | EDNRA (0.49) | EDNRAEDNRBKDRDHPSFLT1 | |
| SCHEMBL4435549 | 0.67 | EDNRB (0.44) | EDNRAEDNRBKDRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0713875-B1 | Sulfonamides | HOFFMANN LA ROCHE (CH) | 2001-03-21 | — | — | EP | disclosed |