Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.50 |
| ▸ | JAK1 | P23458 | 3/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4053733 | 0.85 | JAK3 (0.67) | JAK3JAK1DOT1LLCKHTR2C | |
| SCHEMBL7851091 | 0.79 | JAK3 (0.48) | JAK3JAK1BTKDOT1LLCK | |
| SCHEMBL3539476 | 0.79 | JAK3 (0.60) | JAK3JAK1DOT1LLCK | |
| SCHEMBL7843438 | 0.73 | HTR2C (0.53) | JAK3JAK1LCKHTR2C | |
| SCHEMBL31706717 | 0.72 | JAK3 (0.67) | JAK3JAK1DOT1LLCKHTR2C | |
| SCHEMBL7852410 | 0.72 | JAK3 (0.55) | JAK3JAK1DOT1LLCK | |
| SCHEMBL7851319 | 0.72 | JAK3 (0.51) | JAK3JAK1BTKDOT1L | |
| SCHEMBL3953395 | 0.71 | JAK3 (0.56) | JAK3JAK1DOT1LLCKHTR2C | |
| SCHEMBL6743217 | 0.70 | JAK3 (0.67) | JAK3JAK1DOT1LLCKHTR2C | |
| SCHEMBL31706138 | 0.69 | JAK3 (0.70) | JAK3JAK1DOT1LLCKHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087971-A1 | PYRROLO 2,3-d]PYRIMIDINE COMPOUNDS | Pfizer Products Inc. (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065909-A1 | PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 1999-12-23 | — | — | WO | disclosed |