Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ACE | P12821 | 13/20 | 0.49 |
| ▸ | ACE2 | Q9BYF1 | 6/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7856176 | 0.99 | NPC1 (0.56) | NPC1RAB9AKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL7845289 | 0.88 | ACE (0.59) | ACEACE2TSHR | |
| SCHEMBL7845317 | 0.86 | KMT2A (0.57) | NPC1RAB9AKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL7844672 | 0.83 | HTRA1 (0.52) | ACEACE2TSHR | |
| SCHEMBL7844467 | 0.82 | NPC1 (0.65) | NPC1RAB9AKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL7855038 | 0.81 | KDM4E (0.58) | RAB9AKDM4EACEACE2ALDH1A1 | |
| SCHEMBL7856866 | 0.80 | ACE (0.55) | ACEACE2TSHR | |
| SCHEMBL7852243 | 0.80 | FAP (0.49) | ACEACE2ALDH1A1 | |
| SCHEMBL7844481 | 0.80 | PKM (0.53) | NPC1ACEACE2TSHR | |
| SCHEMBL7845347 | 0.80 | PKM (0.53) | NPC1ACEACE2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709373-B1 | PYRROLIDINE DERIVATIVE | ZAIDAN HOJIN BISEIBUTSU (JP) | 2001-10-17 | — | — | EP | disclosed |
| US-5965556-A | KETO-ACID AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS FOR INHIBITING THE ACTIVITY OF SERINE PROTEASE OR THIOL PROTEASE BY ADMINISTERING THE DERIVATIVE TO A MAMMAL; ALZHEIMER'S DISEASE | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) | 1999-10-12 | — | — | US | disclosed |
| US-5756763-A | ENZYME INHIBITOR | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) | 1998-05-26 | — | — | US | disclosed |
| EP-0709373-A1 | NOVEL PYRROLIDINE DERIVATIVE | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1996-05-01 | — | — | EP | disclosed |