Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | MMP13 | P45452 | 7/20 | 0.61 |
| ▸ | MMP2 | P08253 | 6/20 | 0.61 |
| ▸ | MMP8 | P22894 | 6/20 | 0.61 |
| ▸ | MMP9 | P14780 | 5/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7855259 | 0.92 | NPC1 (0.52) | NPC1RAB9AKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL7854059 | 0.82 | NPC1 (0.57) | NPC1RAB9AKMT2ASMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL7856176 | 0.81 | NPC1 (0.56) | NPC1RAB9AKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL7853929 | 0.80 | NPC1 (0.62) | NPC1RAB9AKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL9564104 | 0.79 | EPHX2 (0.53) | NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL7855306 | 0.75 | ALDH1A1 (0.58) | KMT2ASMN1; SMN2MMP13MMP2MMP8 | |
| SCHEMBL7855232 | 0.74 | FAP (0.46) | NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL7843881 | 0.74 | FAP (0.46) | NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL7852978 | 0.71 | SMN1; SMN2 (0.50) | NPC1RAB9AKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL3456205 | 0.70 | HPGD (1.00) | SMN1; SMN2HPGDHRH3GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709373-B1 | PYRROLIDINE DERIVATIVE | ZAIDAN HOJIN BISEIBUTSU (JP) | 2001-10-17 | — | — | EP | disclosed |
| US-5965556-A | KETO-ACID AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS FOR INHIBITING THE ACTIVITY OF SERINE PROTEASE OR THIOL PROTEASE BY ADMINISTERING THE DERIVATIVE TO A MAMMAL; ALZHEIMER'S DISEASE | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) | 1999-10-12 | — | — | US | disclosed |
| US-5756763-A | ENZYME INHIBITOR | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYUKAI (JP) | 1998-05-26 | — | — | US | disclosed |
| EP-0709373-A1 | NOVEL PYRROLIDINE DERIVATIVE | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1996-05-01 | — | — | EP | disclosed |