Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10186915 | 0.75 | PDCD1 (0.42) | SMN1; SMN2GAANPC1RAB9AKMT2A | |
| SCHEMBL7839454 | 0.74 | KMT2A (0.47) | TDP1SMN1; SMN2GAANPC1RAB9A | |
| SCHEMBL69234 | 0.73 | TDP1 (0.76) | TDP1GLASTING1KDM4EMAPT | |
| SCHEMBL29564952 | 0.73 | TDP1 (0.76) | TDP1GLASTING1KDM4EMAPT | |
| SCHEMBL9510677 | 0.73 | ALOX15 (0.50) | TDP1GLASMN1; SMN2GAANPC1 | |
| SCHEMBL8109553 | 0.72 | ALDH1A1 (0.43) | TDP1KMT2AKDM4EMAPTALDH1A1 | |
| SCHEMBL9193877 | 0.71 | TDP1 (0.61) | TDP1GLASTING1SMN1; SMN2GAA | |
| SCHEMBL11311256 | 0.71 | TDP1 (0.53) | TDP1GLASTING1SMN1; SMN2GAA | |
| SCHEMBL12794312 | 0.70 | EDNRB (0.39) | SMN1; SMN2GAANPC1RAB9AKMT2A | |
| SCHEMBL7849211 | 0.70 | TYMS (0.33) | TDP1GLASMN1; SMN2GAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140946-A2 | QUINOLINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035919-A2 | QUINOLINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2000-06-22 | — | — | WO | disclosed |