Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxolinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | BLM | P54132 | 1/20 | 0.68 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | APEX1 | P27695 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cinoxacin SCHEMBL28034323 | 0.84 | KDM4E (0.97) | KDM4EALDH1A1TSHRLMNABLM | |
| Rosoxacin SCHEMBL13725083 | 0.83 | KDM4E (0.64) | KDM4EALDH1A1TSHRLMNABLM | |
| Cinoxacin SCHEMBL43770 | 0.83 | KDM4E (1.00) | KDM4EALDH1A1TSHRLMNABLM | |
| Cinoxacin SCHEMBL29471771 | 0.83 | KDM4E (1.00) | KDM4EALDH1A1TSHRLMNABLM | |
| Cinoxacin SCHEMBL28034322 | 0.82 | KDM4E (0.97) | KDM4EALDH1A1TSHRLMNABLM | |
| Miloxacin SCHEMBL29386043 | 0.82 | KDM4E (0.65) | KDM4EALDH1A1TSHRLMNABLM | |
| Oxolinic Acid SCHEMBL637058 | 0.82 | KDM4E (1.00) | KDM4EALDH1A1TSHRLMNABLM | |
| Miloxacin SCHEMBL11036965 | 0.82 | KDM4E (0.65) | KDM4EALDH1A1TSHRLMNABLM | |
| Oxolinic Acid SCHEMBL24445 | 0.82 | KDM4E (1.00) | KDM4EALDH1A1TSHRLMNABLM | |
| Miloxacin SCHEMBL152466 | 0.82 | KDM4E (0.65) | KDM4EALDH1A1TSHRLMNABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1083920-A1 | NOVEL ANTIBACTERIAL COMPOUNDS | Advanced Medicine, Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999064051-A1 | NOVEL ANTIBACTERIAL COMPOUNDS | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |