Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rosoxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | BLM | P54132 | 1/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | APEX1 | P27695 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxolinic Acid SCHEMBL7855172 | 0.83 | KDM4E (0.68) | KDM4EALDH1A1LMNATSHRBLM | |
| Rosoxacin SCHEMBL29361483 | 0.82 | CAPN1 (0.61) | KDM4EALDH1A1LMNATSHRHPGD | |
| Rosoxacin SCHEMBL135645 | 0.82 | CAPN1 (0.61) | KDM4EALDH1A1LMNATSHRHPGD | |
| Cinoxacin SCHEMBL4771220 | 0.82 | ALDH1A1 (0.66) | KDM4EALDH1A1LMNATSHRBLM | |
| Cinoxacin SCHEMBL28034323 | 0.81 | KDM4E (0.97) | KDM4EALDH1A1LMNATSHRBLM | |
| Cinoxacin SCHEMBL43770 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1LMNATSHRBLM | |
| Cinoxacin SCHEMBL29471771 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1LMNATSHRBLM | |
| Cinoxacin SCHEMBL28034322 | 0.79 | KDM4E (0.97) | KDM4EALDH1A1LMNATSHRBLM | |
| Oxolinic Acid SCHEMBL637058 | 0.79 | KDM4E (1.00) | KDM4EALDH1A1LMNATSHRBLM | |
| Oxolinic Acid SCHEMBL29420856 | 0.79 | KDM4E (1.00) | KDM4EALDH1A1LMNATSHRBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |
| EP-2699572-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Origenis GmbH (DE) | 2014-02-26 | — | — | EP | disclosed |
| WO-2012143143-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2012-10-26 | — | — | WO | disclosed |