Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 5/20 | 0.62 |
| ▸ | MMP13 | P45452 | 1/20 | 0.62 |
| ▸ | MMP8 | P22894 | 1/20 | 0.55 |
| ▸ | FCER2 | P06734 | 7/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ANPEP | P15144 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | MMP3 | P08254 | 2/20 | 0.48 |
| ▸ | MMP7 | P09237 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8871506 | 0.82 | MMP1 (0.46) | MMP1MMP13FCER2TSHRMMP2 | |
| SCHEMBL6941577 | 0.79 | MMP1 (0.50) | MMP1MMP13MMP8FCER2TSHR | |
| SCHEMBL9714207 | 0.79 | MMP1 (0.48) | MMP1MMP13MMP8FCER2TSHR | |
| SCHEMBL6982654 | 0.79 | MMP1 (0.52) | MMP1MMP13MMP8FCER2TSHR | |
| SCHEMBL7837093 | 0.79 | MMP1 (0.44) | MMP1MMP13MMP3 | |
| SCHEMBL7837095 | 0.79 | MMP1 (0.44) | MMP1MMP13MMP3 | |
| SCHEMBL9714201 | 0.79 | ADAM17 (0.67) | MMP1MMP13MMP8MMP2MMP3 | |
| SCHEMBL3503805 | 0.78 | MMP1 (0.76) | MMP1MMP13MMP8FCER2MMP2 | |
| SCHEMBL30035567 | 0.78 | MMP1 (1.00) | MMP1MMP13MMP8FCER2MMP2 | |
| SCHEMBL13253276 | 0.78 | MMP1 (0.76) | MMP1MMP13MMP8FCER2MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137640-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000035885-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |