SCHEMBL7855602

SCHEMBL7855602

Cc1cn(C2CC2)c2c(C#N)c(Cl)c(F)cc2c1=O

nearest known ligand 0.42

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.39
POLB P06746 1/20 0.39
CHRM2 P08172 1/20 0.39
CHRM1 P11229 1/20 0.39
OPRM1 P35372 1/20 0.39
OPRD1 P41143 1/20 0.39
TOP2A P11388 13/20 0.39
TOP2B Q02880 13/20 0.39
KDM1A O60341 1/20 0.37
KCNH2 Q12809 3/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30468815 0.83 ALDH1A1 (0.57) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL966067 0.83 ALDH1A1 (0.57) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL7646010 0.82 ALDH1A1 (0.47) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL30863948 0.81 STAT3 (0.56) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL5704368 0.81 STAT3 (0.56) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL10435128 0.81 ALDH1A1 (0.44) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL1844834 0.80 ALDH1A1 (0.43) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL7646013 0.75 ALDH1A1 (0.37) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL13341778 0.74 KCNH2 (0.54) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL13341782 0.74 STAT3 (0.39) TOP2ATOP2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1159277-A1 CRYSTAL MODIFICATION D OF 8-CYANO-1-CYCLOPROPYL-7- (1S, 6S- 2,8- DIAZABICYCLO- 4.3.0] NONAN-8-YL) -6-FLUORO -1,4-DIHYDRO -4-OXO -3-QUINOLINE CARBOXYLIC ACID Bayer Aktiengesellschaft (DE) 2001-12-05 EP disclosed
EP-1133495-A1 SEMI-HYDROCHLORIDE OF 8-CYAN-1- CYCLOPROPYL -7-(1S,6S-2 ,8-DIAZABICYCLO 4.3.0]NONAN -8-YL)-6- FLUORO-1, 4-DIHYDRO -4-OXO-3- QUINOLINE CARBOXYLIC ACID Bayer Aktiengesellschaft (DE) 2001-09-19 EP disclosed
EP-1133497-A1 CRYSTAL MODIFICATION B OF 8-CYANO-1- CYCLOPROPYL -7-(1S,6S-2, 8-DIAZABICYCLO 4.3.0]NONAN -8-YL)-6- FLUORO-1,4- DIHYDRO-4- OXO-3-QUINOLINE CARBOXYLIC ACID Bayer Aktiengesellschaft (DE) 2001-09-19 EP disclosed
WO-2000052010-A1 CRYSTAL MODIFICATION D OF 8-CYANO-1-CYCLOPROPYL-7- (1S, 6S- 2,8- DIAZABICYCLO- [4.3.0] NONAN-8-YL) -6-FLUORO -1,4-DIHYDRO -4-OXO -3-QUINOLINE CARBOXYLIC ACID BAYER AKTIENGESELLSCHAFT (DE) 2000-09-08 WO disclosed
WO-2000031077-A1 SEMI-HYDROCHLORIDE OF 8-CYAN-1- CYCLOPROPYL -7-(1S,6S-2 ,8-DIAZABICYCLO [4.3.0]NONAN -8-YL)-6- FLUORO-1, 4-DIHYDRO -4-OXO-3- QUINOLINE CARBOXYLIC ACID BAYER AKTIENGESELLSCHAFT (DE) 2000-06-02 WO disclosed
WO-2000031076-A1 CRYSTAL MODIFICATION B OF 8-CYANO-1- CYCLOPROPYL -7-(1S,6S-2, 8-DIAZABICYCLO [4.3.0]NONAN -8-YL)-6- FLUORO-1,4- DIHYDRO-4- OXO-3-QUINOLINE CARBOXYLIC ACID BAYER AKTIENGESELLSCHAFT (DE) 2000-06-02 WO disclosed