Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 7/20 | 0.37 |
| ▸ | DRD2 | P14416 | 5/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14432505 | 0.86 | DRD3 (0.44) | DRD3DRD2DRD4HTR1AFYN | |
| SCHEMBL7856630 | 0.84 | DRD3 (0.39) | DRD3DRD2DRD4MEN1KMT2A | |
| SCHEMBL27826960 | 0.83 | ADH1A (0.43) | DRD3DRD2DRD4HTR1DHTR1B | |
| SCHEMBL28832059 | 0.81 | MEN1 (0.43) | MEN1KMT2A | |
| SCHEMBL8851207 | 0.80 | DRD3 (0.36) | DRD3DRD2DRD4HTR1DHTR1B | |
| SCHEMBL8851211 | 0.80 | SLC6A4 (0.43) | DRD3DRD2DRD4 | |
| SCHEMBL12957024 | 0.79 | SIGMAR1 (0.37) | DRD3DRD2DRD4 | |
| SCHEMBL27445836 | 0.79 | ADH1C (0.48) | DRD3DRD2 | |
| SCHEMBL6973232 | 0.78 | MEN1 (0.37) | MEN1KMT2A | |
| SCHEMBL3374356 | 0.78 | DRD3 (0.44) | DRD3DRD2DRD4HTR1AFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144403-A1 | SUBSTITUED PYRAZOLES AS P38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000031063-A1 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2000-06-02 | — | — | WO | disclosed |