Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 2/20 | 0.49 |
| ▸ | CAMKK2 | Q96RR4 | 5/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5093362 | 0.90 | VNN1 (0.55) | VNN1CAMKK2MAPK8GSK3BPIK3CG | |
| SCHEMBL5094134 | 0.86 | CAMKK2 (0.54) | VNN1CAMKK2MAPK8GSK3BPIK3CG | |
| SCHEMBL5092162 | 0.84 | MAPK8 (0.61) | CAMKK2MAPK8GSK3BPIK3CGMAPK10 | |
| SCHEMBL5100707 | 0.81 | CAMKK2 (0.49) | VNN1CAMKK2MAPK8GSK3BPIK3CG | |
| SCHEMBL5100280 | 0.79 | HDAC1 (0.53) | VNN1CAMKK2MAPK8GSK3BPIK3CG | |
| SCHEMBL27576350 | 0.77 | CAMKK2 (0.55) | CAMKK2MAPK8GSK3BPIK3CGMAPK10 | |
| SCHEMBL5094793 | 0.76 | MAPK8 (0.58) | CAMKK2MAPK8GSK3BPIK3CGMAPK10 | |
| SCHEMBL5094438 | 0.76 | CAMKK2 (0.54) | VNN1CAMKK2MAPK8GSK3BPIK3CG | |
| SCHEMBL5100273 | 0.76 | CAMK2D (0.55) | VNN1CAMKK2MAPK8GSK3BPIK3CG | |
| SCHEMBL5091408 | 0.76 | CAMKK2 (0.54) | CAMKK2MAPK8GSK3BPIK3CGAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087963-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | Chiron Corporation (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065897-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 1999-12-23 | — | — | WO | disclosed |