Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.47 |
| ▸ | CKS1B | P61024 | 1/20 | 0.46 |
| ▸ | SKP1 | P63208 | 1/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.42 |
| ▸ | ACACB | O00763 | 7/20 | 0.42 |
| ▸ | ACACA | Q13085 | 6/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24986986 | 0.90 | CKS1B (0.56) | DRD2CKS1BSKP1SKP2CHRM4 | |
| SCHEMBL7841697 | 0.85 | CTSK (0.47) | DRD2CKS1BSKP1SKP2DRD3 | |
| SCHEMBL7711219 | 0.79 | DRD2 (0.48) | DRD2CKS1BSKP1SKP2CHRM4 | |
| SCHEMBL2464322 | 0.77 | KCNA3 (0.57) | DRD2CKS1BSKP1SKP2NAMPT | |
| SCHEMBL12835989 | 0.77 | PIM1 (0.58) | DRD2CKS1BSKP1SKP2DRD3 | |
| SCHEMBL8009381 | 0.77 | CHRM4 (0.49) | DRD2CHRM4ADAM17DRD4 | |
| SCHEMBL4871504 | 0.76 | AR (0.50) | DRD2CKS1BSKP1SKP2NAMPT | |
| SCHEMBL8005302 | 0.76 | KCNQ2 (0.47) | DRD2CHRM4ADAM17DRD4DRD3 | |
| SCHEMBL3436642 | 0.75 | CKS1B (0.59) | DRD2CKS1BSKP1SKP2NAMPT | |
| SCHEMBL8005731 | 0.74 | C5AR1 (0.41) | DRD2CHRM4DRD4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019052-A4 | ALPHA 1A ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2001-05-16 | — | — | EP | disclosed |
| US-6143750-A | NITROGEN HETEROCYCLIC COMPOUNDS AS ENZYME INHIBITORS, FOR PROSTATE PROBLEMS AND MUSCLE RELAXANTS | MERCK & CO., INC. (US) | 2000-11-07 | — | — | US | disclosed |
| EP-1019052-A1 | ALPHA 1A ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1998057640-A1 | ALPHA 1A ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |