Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.45 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 4/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1555033 | 0.84 | NPC1 (0.43) | MAP4K1CSNK1DCSNK1EMAPK14NPC1 | |
| SCHEMBL5451902 | 0.82 | IMPDH2 (0.44) | CSNK1DMAPK14ADORA2AADORA1PIM1 | |
| SCHEMBL5256518 | 0.81 | NOTUM (0.52) | CSNK1DMAPK14NPC1RAB9AADORA2A | |
| SCHEMBL27833462 | 0.81 | ATAD2 (0.46) | NPC1RAB9AADORA2AADORA3ADORA1 | |
| SCHEMBL5446421 | 0.81 | MAPK13 (0.47) | MAPK14NPC1RAB9ACDC7TEK | |
| SCHEMBL6077530 | 0.80 | MAPK14 (0.53) | CSNK1DCSNK1EMAPK14 | |
| SCHEMBL1554633 | 0.80 | MAPK14 (0.53) | CSNK1DCSNK1EMAPK14 | |
| SCHEMBL5348452 | 0.79 | CYP11B2 (0.44) | MAPK14TEKIDO1 | |
| SCHEMBL27833455 | 0.79 | IMPDH2 (0.44) | MAP4K1MAPK14ADORA2BIMPDH2 | |
| SCHEMBL27833457 | 0.79 | IMPDH2 (0.44) | MAP4K1MAPK14ADORA2AADORA1CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144403-A1 | SUBSTITUED PYRAZOLES AS P38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000031063-A1 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2000-06-02 | — | — | WO | disclosed |