Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HNF4A | P41235 | 1/20 | 0.44 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CTSA | P10619 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7445918 | 0.85 | MEN1 (0.86) | MEN1KMT2ASMN1; SMN2KEAP1ALDH1A1 | |
| Hydrogen Sulfide SCHEMBL28029146 | 0.83 | MEN1 (0.83) | MEN1KMT2ASMN1; SMN2KEAP1ALDH1A1 | |
| SCHEMBL7855358 | 0.82 | MEN1 (0.64) | MEN1KMT2ASMN1; SMN2KEAP1ALDH1A1 | |
| SCHEMBL6677412 | 0.81 | MEN1 (1.00) | MEN1KMT2ASMN1; SMN2KEAP1ALDH1A1 | |
| SCHEMBL30463435 | 0.81 | MEN1 (1.00) | MEN1KMT2ASMN1; SMN2KEAP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL20578422 | 0.80 | MEN1 (0.96) | MEN1KMT2ASMN1; SMN2KEAP1ALDH1A1 | |
| SCHEMBL3791684 | 0.79 | SMN1; SMN2 (0.52) | MEN1KMT2ASMN1; SMN2KEAP1ALDH1A1 | |
| SCHEMBL8569633 | 0.79 | MEN1 (0.64) | MEN1KMT2ASMN1; SMN2KEAP1ALDH1A1 | |
| SCHEMBL7855886 | 0.79 | MEN1 (0.64) | MEN1KMT2ASMN1; SMN2KEAP1ALDH1A1 | |
| SCHEMBL3760398 | 0.79 | MEN1 (0.74) | MEN1KMT2ASMN1; SMN2KEAP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1094816-A4 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2001-12-19 | — | — | EP | claimed |
| EP-1094816-A1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-05-02 | — | — | EP | claimed |
| WO-2000001389-A1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB CO. (US) | 2000-01-13 | — | — | WO | claimed |