Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HNF4A | P41235 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8573478 | 0.90 | MEN1 (0.58) | MEN1KMT2ASMN1; SMN2KEAP1NR1H4 | |
| SCHEMBL7445918 | 0.82 | MEN1 (0.86) | MEN1KMT2ASMN1; SMN2KEAP1ALDH1A1 | |
| SCHEMBL8570513 | 0.81 | MEN1 (0.62) | MEN1KMT2ASMN1; SMN2KEAP1HTT | |
| Hydrogen Sulfide SCHEMBL28029146 | 0.81 | MEN1 (0.83) | MEN1KMT2ASMN1; SMN2KEAP1ALDH1A1 | |
| SCHEMBL30463435 | 0.79 | MEN1 (1.00) | MEN1KMT2ASMN1; SMN2KEAP1ALDH1A1 | |
| SCHEMBL6677412 | 0.79 | MEN1 (1.00) | MEN1KMT2ASMN1; SMN2KEAP1ALDH1A1 | |
| SCHEMBL7856359 | 0.79 | MEN1 (0.68) | MEN1KMT2ASMN1; SMN2KEAP1HTT | |
| SCHEMBL30394743 | 0.78 | HNF4A (0.58) | MEN1KMT2ASMN1; SMN2NR1H4HTT | |
| SCHEMBL4632581 | 0.78 | HNF4A (0.58) | MEN1KMT2ASMN1; SMN2NR1H4HTT | |
| SCHEMBL27890118 | 0.78 | NR1H4 (0.56) | MEN1KMT2ASMN1; SMN2NR1H4HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | disclosed |