Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.86 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.86 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.86 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 2/20 | 0.48 |
| ▸ | HNF4A | P41235 | 1/20 | 0.46 |
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | FABP3 | P05413 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.42 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrogen Sulfide SCHEMBL28029146 | 0.98 | MEN1 (0.83) | MEN1KMT2ASMN1; SMN2ALDH1A1KEAP1 | |
| SCHEMBL30463435 | 0.92 | MEN1 (1.00) | MEN1KMT2ASMN1; SMN2ALDH1A1KEAP1 | |
| SCHEMBL6677412 | 0.92 | MEN1 (1.00) | MEN1KMT2ASMN1; SMN2ALDH1A1KEAP1 | |
| Hydrochloric Acid SCHEMBL20578422 | 0.91 | MEN1 (0.96) | MEN1KMT2ASMN1; SMN2ALDH1A1KEAP1 | |
| SCHEMBL7856359 | 0.85 | MEN1 (0.68) | MEN1KMT2ASMN1; SMN2ALDH1A1KEAP1 | |
| SCHEMBL7855886 | 0.82 | MEN1 (0.64) | MEN1KMT2ASMN1; SMN2ALDH1A1KEAP1 | |
| SCHEMBL7407290 | 0.82 | KMT2A (0.64) | MEN1KMT2ASMN1; SMN2ALDH1A1KEAP1 | |
| SCHEMBL8569633 | 0.82 | MEN1 (0.64) | MEN1KMT2ASMN1; SMN2ALDH1A1KEAP1 | |
| SCHEMBL3760398 | 0.82 | MEN1 (0.74) | MEN1KMT2ASMN1; SMN2ALDH1A1KEAP1 | |
| SCHEMBL8573571 | 0.80 | MEN1 (0.60) | MEN1KMT2ASMN1; SMN2ALDH1A1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921800-A4 | SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL MYERS SQUIBB CO (US) | 2000-12-06 | — | — | EP | claimed |
| EP-0921800-A1 | SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-06-16 | — | — | EP | claimed |
| WO-1997029748-A1 | SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-08-21 | — | — | WO | claimed |