Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8351681 | 1.00 | CYP3A4 (0.46) | CYP3A4MEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL8350180 | 0.87 | ALDH1A1 (0.48) | CYP3A4MEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL7845703 | 0.87 | ALDH1A1 (0.48) | CYP3A4MEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL10479311 | 0.85 | CYP3A4 (0.48) | CYP3A4MEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL8351699 | 0.85 | MEN1 (0.63) | CYP3A4MEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL10479312 | 0.85 | CYP3A4 (0.48) | CYP3A4MEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL8351696 | 0.85 | MEN1 (0.63) | CYP3A4MEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL7855278 | 0.82 | MAPT (0.46) | CYP3A4MEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL8349840 | 0.82 | MAPT (0.46) | CYP3A4MEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL7994113 | 0.81 | NFE2L2 (0.42) | ALDH1A1CYP1A2MAPTAHRPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726257-B1 | 1-(Hetero)Arylvinyl-5H-2,3-benzodiazepine derivatives useful for the treatment of central nervous system disorders, and benzopyrylium intermediates for their preparation | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 2001-04-11 | — | — | EP | disclosed |
| US-5942506-A | TREATMENT OF NERVOUS SYSTEM DISORDERS, ANXIETY | GIS GYOGYSZERGYAR RT. (HU) | 1999-08-24 | — | — | US | disclosed |
| EP-0726257-A1 | 1-(Hetero)Arylvinyl-5H-2,3-benzodiazepine derivatives useful for the treatment of central nervous system disorders, and benzopyrylium intermediates for their preparation | EGIS GYOGYSZERGYAR RT. (HU) | 1996-08-14 | — | — | EP | disclosed |