Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPGS | Q05932 | 3/20 | 0.48 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 8/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | GART | P22102 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2222227 | 0.76 | FPGS (0.65) | FPGSSOSTNOS1NOS3NOS2 | |
| SCHEMBL2224654 | 0.74 | FPGS (0.55) | FPGSSOSTNOS1NOS3NOS2 | |
| SCHEMBL2223139 | 0.74 | FPGS (0.54) | FPGSSOSTNOS1NOS3NOS2 | |
| Tetrahydrofolate SCHEMBL23630632 | 0.68 | SOST (0.92) | FPGSSOSTGARTDHFRMTHFD2 | |
| Tetrahydrofolate SCHEMBL21248573 | 0.68 | SOST (0.92) | FPGSSOSTGARTDHFRMTHFD2 | |
| Tetrahydrofolate SCHEMBL4628326 | 0.68 | SOST (0.92) | FPGSSOSTGARTDHFRMTHFD2 | |
| SCHEMBL28206357 | 0.67 | SOST (0.79) | FPGSSOSTNOS1NOS3NOS2 | |
| SCHEMBL2922792 | 0.67 | SOST (0.70) | FPGSSOSTNOS1NOS3NOS2 | |
| SCHEMBL30424027 | 0.67 | SOST (0.70) | FPGSSOSTNOS1NOS3NOS2 | |
| Tetrahydrofolate SCHEMBL27727181 | 0.66 | SOST (0.87) | FPGSSOSTGARTDHFRMTHFD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923287-A4 | NONCLASSICAL PYRROLO 2,3-D]PYRIMIDINE ANTIFOLATES | LILLY CO ELI (US) | 2001-08-01 | — | — | EP | disclosed |
| EP-0923287-A1 | NONCLASSICAL PYRROLO 2,3-D]PYRIMIDINE ANTIFOLATES | ELI LILLY AND COMPANY (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998008382-A1 | NONCLASSICAL PYRROLO[2,3-D]PYRIMIDINE ANTIFOLATES | ELI LILLY AND COMPANY (US) | 1998-03-05 | — | — | WO | disclosed |