Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 6/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 6/20 | 0.48 |
| ▸ | TAS1R2 | Q8TE23 | 4/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL785637 | 1.00 | TAS1R3 (0.48) | TAS1R3TAS1R1TAS1R2PDE4APDE4B | |
| SCHEMBL785911 | 0.88 | PDE4A (0.49) | TAS1R3TAS1R1TAS1R2PDE4APDE4B | |
| SCHEMBL785910 | 0.88 | PDE4A (0.49) | TAS1R3TAS1R1TAS1R2PDE4APDE4B | |
| SCHEMBL785085 | 0.87 | TAS1R3 (0.44) | TAS1R3TAS1R1TAS1R2PDE4APDE4B | |
| SCHEMBL785084 | 0.87 | TAS1R3 (0.44) | TAS1R3TAS1R1TAS1R2PDE4APDE4B | |
| SCHEMBL784599 | 0.84 | HTT (0.62) | TAS1R3TAS1R1TAS1R2PDE4APDE4B | |
| SCHEMBL784469 | 0.84 | HTT (0.62) | TAS1R3TAS1R1TAS1R2PDE4APDE4B | |
| SCHEMBL785249 | 0.84 | ALDH1A1 (0.61) | TAS1R3TAS1R1TAS1R2PDE4APDE4B | |
| SCHEMBL485045 | 0.84 | MEN1 (0.51) | TAS1R3TAS1R1TAS1R2PDE4APDE4B | |
| SCHEMBL485126 | 0.84 | ALDH1A1 (0.61) | TAS1R3TAS1R1TAS1R2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680159-B2 | Bradykinin 1 receptor modulating compounds | GRUENENTHAL GMBH (DE) | 2014-03-25 | — | — | US | disclosed |
| EP-2619178-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2013-07-31 | — | — | EP | disclosed |
| CN-103097354-A | Substituted benzamide compounds | GRUENENTHAL CHEMIE | 2013-05-08 | — | — | CN | disclosed |
| WO-2012038081-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-03-29 | — | — | WO | disclosed |
| US-20120071461-A1 | Substituted Benzamide Compounds | GRUENENTHAL GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071461-A1 | Substituted Benzamide Compounds | BDKRB1, BDKRB2, HRH2 | TAS1R3 202/4885TAS1R1 75/4885TAS1R2 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.