SCHEMBL7859592

SCHEMBL7859592

N#Cc1ccc(N)c(NS(=O)(=O)c2ccccc2)c1

nearest known ligand 0.51

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SLC22A12 Q96S37 2/20 0.51
ACLY P53396 4/20 0.50
PTGES2 Q9H7Z7 2/20 0.50
CCR2 P41597 1/20 0.49
FFAR4 Q5NUL3 2/20 0.48
PGR P06401 1/20 0.47
CYP19A1 P11511 1/20 0.47
KDM4E B2RXH2 1/20 0.47
ALDH1A1 P00352 1/20 0.47
GAA P10253 1/20 0.47
GLO1 Q04760 2/20 0.45
SLC40A1 Q9NP59 1/20 0.45
STAT3 P40763 1/20 0.44
HTR6 P50406 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7589336 0.86 SLC22A12 (0.54) SLC22A12ACLYPTGES2CCR2PGR
SCHEMBL7940030 0.83 HDAC1 (0.50) SLC22A12ACLYPTGES2CCR2
SCHEMBL18299624 0.82 SLC22A12 (0.51) SLC22A12ACLYPTGES2CCR2PGR
SCHEMBL18299831 0.79 SLC22A12 (0.51) SLC22A12ACLYPTGES2CCR2PGR
SCHEMBL21865747 0.79 RXFP1 (0.55) SLC22A12ACLYPTGES2FFAR4PGR
SCHEMBL21866537 0.78 GAA (0.52) SLC22A12ACLYPTGES2CCR2FFAR4
SCHEMBL27519445 0.78 MAPT (0.60) SLC22A12ACLYPTGES2CCR2FFAR4
SCHEMBL7557174 0.76 PTGES2 (0.45) ACLYPTGES2CCR2ALDH1A1GAA
SCHEMBL30737452 0.76 ALDH1A1 (0.58) FFAR4ALDH1A1GAAGLO1SLC40A1
SCHEMBL2068236 0.76 ALDH1A1 (0.58) FFAR4ALDH1A1GAAGLO1SLC40A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1539816-A IL-8 receptor antagonists ʷ��˿�������ȳ�ķ���޹�˾ 2004-10-27 CN disclosed
CN-1355697-A IL-8 receptor antagonists SMITHKLINE BEECHAM CORP (US) 2002-06-26 CN disclosed
EP-0915651-A4 IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2001-10-24 EP disclosed
EP-0912505-A4 IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2001-10-24 EP disclosed
US-6271261-B1 CHEMOKINE MEDIATED DISEASES, BINDING INTERLEUKINS OR BETA-RECEPTORS AND ADMINISTERING TO MAMMALS SMITHKLINE BEECHAM CORPORATION 2001-08-07 US disclosed
US-6133319-A IL-8 receptor antagonists SMITHKLINE BEECHAM CORPORATION (US) 2000-10-17 US disclosed
EP-0915651-A1 IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1999-05-19 EP disclosed
EP-0912505-A1 IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1999-05-06 EP disclosed
CN-1215990-A IL-8 receptor antagonists SMITHKLINE BEECHAM CORP (US) 1999-05-05 CN disclosed
WO-1997049680-A1 IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1997-12-31 WO disclosed
WO-1997049286-A1 IL-8 RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1997-12-31 WO disclosed