Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.38 |
| ▸ | CDK9 | P50750 | 4/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7870782 | 0.81 | HRH4 (0.50) | MAPK14CCNT1CDK9CASP3CASP7 | |
| Bromide SCHEMBL7859742 | 0.81 | MAPK14 (0.48) | MAPK14CCNT1CDK9CASP3CASP7 | |
| SCHEMBL15219331 | 0.77 | HRH4 (0.55) | CCNT1CDK9 | |
| SCHEMBL7203954 | 0.76 | HRH4 (0.53) | — | |
| Bromide SCHEMBL8820626 | 0.74 | CDK9 (0.45) | CCNT1CDK9CASP3CASP7 | |
| Bromide SCHEMBL7865092 | 0.74 | HRH4 (0.51) | MAPK14CCNT1CDK9 | |
| SCHEMBL11916126 | 0.74 | HRH4 (0.41) | MAPK14 | |
| SCHEMBL7503773 | 0.72 | HRH4 (0.52) | MAPK14CCNT1CDK9 | |
| SCHEMBL26684171 | 0.69 | YTHDF2 (0.43) | MAPK14 | |
| SCHEMBL7867370 | 0.68 | APP (0.65) | APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |