Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.51 |
| ▸ | RXRA | P19793 | 2/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.43 |
| ▸ | BCHE | P06276 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9544537 | 0.89 | SLC6A4 (0.41) | ABCB1KMT2AATMAPPMTNR1A | |
| SCHEMBL7861112 | 0.82 | ATM (0.45) | RXRAKMT2AATMAPPMTNR1A | |
| SCHEMBL7854387 | 0.81 | ALDH1A1 (0.45) | RXRATDP1L3MBTL1RXRBRXRG | |
| SCHEMBL7861235 | 0.81 | ALDH1A1 (0.48) | RXRAATMTDP1L3MBTL1RXRB | |
| SCHEMBL7861313 | 0.79 | KDM4E (0.45) | KMT2AATMMTNR1AL3MBTL1MEN1 | |
| Butane SCHEMBL9544535 | 0.77 | ABCB1 (0.42) | ABCB1APPMTNR1AMTNR1B | |
| SCHEMBL7714028 | 0.75 | FFAR1 (0.55) | FFAR1KMT2AL3MBTL1MEN1 | |
| SCHEMBL7860078 | 0.75 | ALDH1A1 (0.47) | ABCB1FFAR1KMT2AGLAL3MBTL1 | |
| SCHEMBL7712069 | 0.74 | FFAR1 (0.53) | FFAR1KMT2AL3MBTL1MEN1 | |
| SCHEMBL8505531 | 0.73 | FFAR1 (0.52) | FFAR1KMT2AL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625969-B1 | ARYLALKOXYPHENOXY-IMIDAZOLINE COMPOUNDS | MERRELL PHARMA INC (US) | 2001-03-07 | — | — | EP | disclosed |
| US-5407954-A | Serotonin antagonism; treats depression, anxiety, hypertension and migraine headaches | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-04-18 | — | — | US | disclosed |
| EP-0625969-A1 | ARYLALKOXYPHENOXY-IMIDAZOLINE COMPOUNDS | MERRELL PHARMACEUTICALS INC. (US) | 1994-11-30 | — | — | EP | disclosed |
| US-5216008-A | Antidepressant, anxiolytic, hypotensive and also treats migraine headaches | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-01 | — | — | US | disclosed |