Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLNR | O43193 | 8/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7854631 | 0.88 | MLNR (0.52) | MLNRCYP2D6DRD2DRD3TPSAB1 | |
| SCHEMBL7860289 | 0.85 | MLNR (0.52) | MLNRCYP2D6DRD2DRD3TPSAB1 | |
| SCHEMBL12608373 | 0.78 | HRH3 (0.51) | MLNRCYP2D6DRD2DRD3HTR2C | |
| SCHEMBL7862464 | 0.77 | TPSAB1 (0.47) | TPSAB1ALDH1A1HTR2CHTR2BMAPT | |
| SCHEMBL1789401 | 0.76 | MLNR (0.74) | MLNRCYP2D6HTR2CHTR2BHTR6 | |
| SCHEMBL7854715 | 0.75 | ALDH1A1 (0.46) | TPSAB1ALDH1A1HTR2CHTR2BMAPT | |
| SCHEMBL20097742 | 0.74 | DRD1 (0.49) | MLNRCYP2D6DRD2DRD3HTR2C | |
| SCHEMBL7861299 | 0.74 | NPC1 (0.44) | CYP2D6ALDH1A1MAPTKDM4E | |
| SCHEMBL7862501 | 0.74 | NPC1 (0.41) | CYP2D6TPSAB1ALDH1A1HTR2CHTR2B | |
| SCHEMBL12651580 | 0.74 | MLNR (0.50) | MLNRCYP2D6DRD2DRD3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807101-B1 | 2-AMINOINDANS AS SELECTIVE DOPAMINE D3 LIGANDS | UPJOHN CO (US) | 2001-06-13 | — | — | EP | disclosed |
| US-5936000-A | 2-aminoindans as selective dopamine D3 ligands | PHARMACIA & UPJOHN COMPANY (US) | 1999-08-10 | — | — | US | disclosed |
| WO-1996023760-A1 | 2-AMINOINDANS AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1996-08-08 | — | — | WO | disclosed |