Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LSS | P48449 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7861583 | 0.89 | CYP19A1 (0.54) | CYP19A1DRD3LSSDRD2 | |
| SCHEMBL7861350 | 0.85 | CYP19A1 (0.44) | CYP19A1FYNDRD3ALDH1A1CYP2D6 | |
| SCHEMBL7408204 | 0.83 | DRD3 (0.54) | CYP19A1DRD3CYP2D6DRD2 | |
| SCHEMBL7408200 | 0.83 | DRD3 (0.54) | CYP19A1DRD3CYP2D6DRD2 | |
| SCHEMBL7862454 | 0.78 | CYP19A1 (0.45) | CYP19A1DRD3DRD2 | |
| SCHEMBL8094256 | 0.76 | DRD3 (0.54) | DRD3CYP2D6CYP2C9DRD2 | |
| SCHEMBL8094252 | 0.76 | DRD3 (0.54) | DRD3CYP2D6CYP2C9DRD2 | |
| SCHEMBL7860190 | 0.76 | FYN (0.41) | FYNDRD3ALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL7860284 | 0.76 | DRD3 (0.63) | FYNDRD3DRD2 | |
| SCHEMBL7864511 | 0.75 | FYN (0.50) | FYNDRD3ALDH1A1CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807101-B1 | 2-AMINOINDANS AS SELECTIVE DOPAMINE D3 LIGANDS | UPJOHN CO (US) | 2001-06-13 | — | — | EP | disclosed |
| US-5936000-A | 2-aminoindans as selective dopamine D3 ligands | PHARMACIA & UPJOHN COMPANY (US) | 1999-08-10 | — | — | US | disclosed |
| EP-0807101-A1 | 2-AMINOINDANS AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1997-11-19 | — | — | EP | disclosed |
| WO-1996023760-A1 | 2-AMINOINDANS AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1996-08-08 | — | — | WO | disclosed |