Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 5/20 | 0.48 |
| ▸ | THRB | P10828 | 5/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | MMP9 | P14780 | 2/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | RARB | P10826 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7860406 | 1.00 | THRA (0.48) | THRATHRBTP53TSHRMAPT | |
| SCHEMBL7860409 | 1.00 | THRA (0.48) | THRATHRBTP53TSHRMAPT | |
| SCHEMBL7854961 | 1.00 | THRA (0.48) | THRATHRBTP53TSHRMAPT | |
| SCHEMBL27522150 | 0.95 | MMP2 (0.46) | THRATHRBTP53TSHRMAPT | |
| SCHEMBL27522152 | 0.93 | MMP2 (0.43) | THRATHRBTP53TSHRMAPT | |
| SCHEMBL7854992 | 0.86 | MMP2 (0.52) | THRATHRBMMP2MMP9 | |
| SCHEMBL4318837 | 0.86 | MMP2 (0.56) | MAPTMMP2MMP9MMP1MMP3 | |
| SCHEMBL30249505 | 0.86 | MMP2 (0.56) | MAPTMMP2MMP9MMP1MMP3 | |
| SCHEMBL7861661 | 0.84 | NPC1 (0.62) | TP53MAPTRAB9AMMP2MMP9 | |
| SCHEMBL7865130 | 0.83 | MMP2 (0.51) | MMP2MMP9MMP3MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923529-B1 | SUBSTITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS | BAYER AG (US) | 2001-09-19 | — | — | EP | disclosed |
| US-5863915-A | ENZYME INHIBITORS FOR BONES AND JOINTS | BAYER CORPORATION (US) | 1999-01-26 | — | — | US | disclosed |