Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 4/20 | 0.65 |
| ▸ | KDR | P35968 | 8/20 | 0.51 |
| ▸ | BRAF | P15056 | 3/20 | 0.51 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Picolinic Acid SCHEMBL7860597 | 0.90 | GRM4 (0.67) | GRM4KDRBRAFFLT3KIT | |
| SCHEMBL7178922 | 0.87 | GRM4 (0.86) | GRM4KDRBRAFFLT3KIT | |
| SCHEMBL6815777 | 0.85 | KDR (0.61) | GRM4KDRBRAFFLT3KIT | |
| SCHEMBL6815026 | 0.77 | ALDH1A1 (0.51) | KDRBRAFFLT3KITALDH1A1 | |
| SCHEMBL7162138 | 0.76 | KDR (0.78) | KDRRAF1TRPV1 | |
| SCHEMBL8562560 | 0.76 | BRAF (0.64) | GRM4KDRBRAFFLT3KIT | |
| SCHEMBL6816279 | 0.74 | LMNA (0.60) | KDRALDH1A1GAAMAPTMEN1 | |
| SCHEMBL7981202 | 0.74 | MAPK14 (0.56) | GRM4KDRALDH1A1GAAMAPT | |
| SCHEMBL4555026 | 0.73 | LMNA (0.75) | GRM4KDRBRAFRAF1ALDH1A1 | |
| SCHEMBL7570587 | 0.73 | BRAF (0.55) | GRM4KDRBRAFALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137645-A2 | ALPHA-METHYLBENZYL-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A PHENYLENEDIAMINE GROUP | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000034260-A2 | ALPHA-METHYLBENZYL-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A PHENYLENEDIAMINE GROUP | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |