Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.53 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzenesulfonamide SCHEMBL7050658 | 0.95 | PTGS2 (0.62) | PTGS2PTGS1 | |
| Imidazole SCHEMBL7930105 | 0.90 | PTGS2 (0.46) | PTGS2PTGS1SYK | |
| SCHEMBL8347213 | 0.88 | PTGS2 (0.55) | PTGS2PTGS1SYK | |
| SCHEMBL8348990 | 0.84 | PTGS2 (0.54) | PTGS2PTGS1SYK | |
| Benzenesulfonamide SCHEMBL7932083 | 0.80 | PTGS2 (0.62) | PTGS2PTGS1 | |
| Benzenesulfonamide SCHEMBL7189185 | 0.79 | PTGS2 (0.61) | PTGS2PTGS1 | |
| SCHEMBL8025611 | 0.79 | PTGS2 (0.55) | PTGS2PTGS1 | |
| SCHEMBL7932077 | 0.79 | PTGS2 (0.55) | PTGS2PTGS1 | |
| SCHEMBL8346344 | 0.77 | PTGS2 (0.55) | PTGS2PTGS1 | |
| SCHEMBL8350247 | 0.77 | PTGS2 (0.55) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140181-A1 | COMBINATION THERAPY OF RADIATION AND A COX-2 INHIBITOR FOR THE TREATMENT OF NEOPLASIA | G.D. SEARLE & CO. (US) | 2001-10-10 | — | — | EP | claimed |
| WO-2000038716-A1 | COMBINATION THERAPY OF RADIATION AND A COX-2 INHIBITOR FOR THE TREATMENT OF NEOPLASIA | G.D. SEARLE & CO. (US) | 2000-07-06 | — | — | WO | claimed |