Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzenesulfonamide SCHEMBL7932083 | 0.95 | PTGS2 (0.62) | PTGS2PTGS1 | |
| SCHEMBL7860657 | 0.84 | PTGS2 (0.54) | PTGS2PTGS1SYK | |
| SCHEMBL8350247 | 0.84 | PTGS2 (0.55) | PTGS2PTGS1 | |
| SCHEMBL8347213 | 0.83 | PTGS2 (0.55) | PTGS2PTGS1SYK | |
| SCHEMBL7932077 | 0.81 | PTGS2 (0.55) | PTGS2PTGS1SLC22A12 | |
| SCHEMBL7773789 | 0.80 | PTGS2 (0.50) | PTGS2PTGS1 | |
| Benzenesulfonamide SCHEMBL7050658 | 0.80 | PTGS2 (0.62) | PTGS2PTGS1 | |
| Benzenesulfonamide SCHEMBL7189185 | 0.79 | PTGS2 (0.61) | PTGS2PTGS1 | |
| SCHEMBL8025611 | 0.79 | PTGS2 (0.55) | PTGS2PTGS1 | |
| Pyridine SCHEMBL7918818 | 0.79 | PTGS2 (0.50) | PTGS2PTGS1SLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5700816-A | ANTIARTHRITIC AGENTS | G.D. SEARLE & CO. | 1997-12-23 | — | — | US | claimed |
| US-5932598-A | NOVEL SUBSTITUTED SULFONAMIDE COMPOUNDS USEFUL AS PRODRUGS; ADMINISTERING TO TREAT INFLAMMATION-ASSOCIATED PAIN DUE TO CANCER, DENTAL PAIN; CYCLOOXYGENASE-2 INHIBITORS | G. D. SEARLE & CO. (US) | 1999-08-03 | — | — | US | disclosed |
| US-5700816-A | ANTIARTHRITIC AGENTS | G.D. SEARLE & CO. | 1997-12-23 | — | — | US | disclosed |