Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.53 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL7918818 | 0.95 | PTGS2 (0.50) | PTGS2PTGS1SLC22A12RXRANR1H2 | |
| SCHEMBL8350247 | 0.85 | PTGS2 (0.55) | PTGS2PTGS1 | |
| SCHEMBL8348990 | 0.81 | PTGS2 (0.54) | PTGS2PTGS1SLC22A12 | |
| SCHEMBL8346344 | 0.81 | PTGS2 (0.55) | PTGS2PTGS1 | |
| Benzenesulfonamide SCHEMBL7189185 | 0.80 | PTGS2 (0.61) | PTGS2PTGS1 | |
| SCHEMBL8025611 | 0.80 | PTGS2 (0.55) | PTGS2PTGS1RXRANR1H2NR1H3 | |
| SCHEMBL7867027 | 0.80 | PTGS2 (0.43) | PTGS2PTGS1 | |
| SCHEMBL7860657 | 0.79 | PTGS2 (0.54) | PTGS2PTGS1 | |
| SCHEMBL8347213 | 0.78 | PTGS2 (0.55) | PTGS2PTGS1RXRANR1H2NR1H3 | |
| Benzenesulfonamide SCHEMBL7932083 | 0.77 | PTGS2 (0.62) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2001527542-A | — | — | 2001-12-25 | — | — | JP | claimed |
| EP-0979077-A1 | METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS IN THE PREVENTION OF CARDIOVASCULAR DISORDERS | G.D. Searle & Co. (US) | 2000-02-16 | — | — | EP | claimed |
| WO-1998047509-A1 | METHOD OF USING CYCLOOXYGENASE-2 INHIBITORS IN THE PREVENTION OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1998-10-29 | — | — | WO | claimed |