Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 4/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7861143 | 0.88 | PTGS2 (0.39) | FEN1ALOX5APPTGS2KDM4EMITF | |
| SCHEMBL16661274 | 0.72 | KDM4E (0.45) | KDM4ELMNASMN1; SMN2 | |
| SCHEMBL7775612 | 0.72 | POLB (0.44) | FEN1ALOX5APPTGS2KDM4EMITF | |
| SCHEMBL5597397 | 0.70 | PTGS2 (0.50) | PTGS2KDM4EMITFALDH1A1LMNA | |
| SCHEMBL6532907 | 0.70 | PTGS2 (0.50) | PTGS2MAP4K4PIK3CAKCNH2MINK1 | |
| SCHEMBL25276213 | 0.69 | NT5E (0.38) | FEN1ALOX5APKDM4E | |
| SCHEMBL7855636 | 0.69 | ALOX5AP (0.31) | FEN1ALOX5APPTGS2RAB9ASMN1; SMN2 | |
| SCHEMBL27174299 | 0.69 | ALOX5AP (0.43) | FEN1ALOX5APPTGS2PTGS1 | |
| SCHEMBL27031500 | 0.68 | NT5E (0.37) | PTGS2KDM4E | |
| SCHEMBL7144668 | 0.68 | PTGS2 (0.49) | PTGS2MAP4K4PIK3CAKCNH2MINK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086097-A1 | SULFONYLBENZENE COMPOUNDS AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | PFIZER INC. (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999064415-A1 | SULFONYLBENZENE COMPOUNDS AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-12-16 | — | — | WO | disclosed |