Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.36 |
| ▸ | TYMP | P19971 | 1/20 | 0.34 |
| ▸ | SDHB | P21912 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7861157 | 0.88 | FEN1 (0.35) | PTGS2PTGS1SDHBKDM4EMITF | |
| SCHEMBL5597397 | 0.70 | PTGS2 (0.50) | PTGS2PTGS1KDM4EMITFALDH1A1 | |
| SCHEMBL7144668 | 0.70 | PTGS2 (0.49) | PTGS2PTGS1SDHB | |
| SCHEMBL7775612 | 0.69 | POLB (0.44) | PTGS2SDHBKDM4EMITFALDH1A1 | |
| SCHEMBL27174299 | 0.68 | ALOX5AP (0.43) | PTGS2PTGS1ALOX5APFEN1 | |
| SCHEMBL27031500 | 0.68 | NT5E (0.37) | PTGS2KDM4E | |
| SCHEMBL6532907 | 0.68 | PTGS2 (0.50) | PTGS2PTGS1 | |
| SCHEMBL6516190 | 0.67 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL25281827 | 0.67 | KDM4E (0.37) | PTGS2PTGS1TYMPKDM4E | |
| SCHEMBL6448449 | 0.65 | SDHB (0.52) | PTGS2PTGS1SDHB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086097-A1 | SULFONYLBENZENE COMPOUNDS AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | PFIZER INC. (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999064415-A1 | SULFONYLBENZENE COMPOUNDS AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-12-16 | — | — | WO | disclosed |