Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 0.50 |
| ▸ | TDO2 | P48775 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7144668 | 0.91 | PTGS2 (0.49) | PTGS2TDO2PTGS1 | |
| SCHEMBL6448449 | 0.83 | SDHB (0.52) | PTGS2PTGS1 | |
| SCHEMBL7147045 | 0.81 | PTGS2 (0.55) | PTGS2LMNASMN1; SMN2NPSR1PTGS1 | |
| SCHEMBL6175783 | 0.81 | MAPK11 (0.52) | PTGS2TDO2ALDH1A1SMN1; SMN2 | |
| SCHEMBL6532907 | 0.79 | PTGS2 (0.50) | PTGS2PTGS1 | |
| SCHEMBL26093883 | 0.74 | KDM4E (0.44) | KDM4EMITFALDH1A1LMNASTAT3 | |
| SCHEMBL5084380 | 0.74 | PTGS2 (0.50) | PTGS2KDM4EMITFALDH1A1LMNA | |
| SCHEMBL8908072 | 0.73 | PTGS2 (0.56) | PTGS2PTGS1 | |
| SCHEMBL6913549 | 0.71 | PTGS2 (0.65) | PTGS2 | |
| SCHEMBL7861157 | 0.70 | FEN1 (0.35) | PTGS2KDM4EMITFALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1039914-A4 | CYCLOOXYGENASE-2 INHIBITION | CORNELL RES FOUNDATION INC (US) | 2007-06-27 | — | — | EP | disclosed |
| EP-1039914-A1 | CYCLOOXYGENASE-2 INHIBITION | CORNELL RESEARCH FOUNDATION, INC. (US) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999030721-A1 | CYCLOOXYGENASE-2 INHIBITION | CORNELL RESEARCH FOUNDATION, INC. (US) | 1999-06-24 | — | — | WO | disclosed |