Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4411573 | 0.79 | PGR (0.38) | PGRADRA2AADRA2BHTR2AHRH1 | |
| SCHEMBL609709 | 0.79 | TSHR (0.46) | PGRADRA2AADRA2BHTR2AHRH1 | |
| SCHEMBL11856683 | 0.77 | MEN1 (0.35) | PGRADRA2AADRA2BHTR2AHRH1 | |
| Hydrochloric Acid SCHEMBL28375443 | 0.77 | TSHR (0.44) | PGRADRA2AADRA2BHTR2AHRH1 | |
| SCHEMBL11749635 | 0.77 | LMNA (0.42) | PGRADRA2AADRA2BHTR2AHRH1 | |
| SCHEMBL28664167 | 0.77 | PGR (0.33) | PGRADRA2AADRA2BHTR2AHRH1 | |
| SCHEMBL358238 | 0.74 | LMNA (0.52) | MAPT | |
| SCHEMBL11867821 | 0.74 | ALDH1A1 (0.44) | PGRADRA2AADRA2BHTR2AHRH1 | |
| SCHEMBL6979242 | 0.72 | MEN1 (0.31) | — | |
| SCHEMBL14873 | 0.72 | TSHR (0.44) | PGRADRA2AADRA2BHTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418099-B1 | Process of preparation of 10, 11-Methylenedioxy-20 (RS) camptothecin and 10, 11-methylenedioxy-20 (S) - camptothecin analog | RES TRIANGLE INST (US) | 2001-12-19 | — | — | EP | disclosed |
| US-5340817-A | Method of treating tumors with anti-tumor effective camptothecin compounds | RESEARCH TRIANGLE INSTITUTE (US) | 1994-08-23 | — | — | US | disclosed |
| US-5180722-A | Topisomerase Inhibitors, Anticarcinogenic Agents | RESEARCH TRIANGLE INSTITUTE (US) | 1993-01-19 | — | — | US | disclosed |
| US-5049668-A | 10,11-methylenedioxy-20(RS)-camptothecin analogs | RESEARCH TRIANGLE INSTITUTE (US) | 1991-09-17 | — | — | US | disclosed |
| EP-0418099-A2 | 10, 11-Methylenedioxy-20 (RS) camptothecin and 10, 11-methylenedioxy-20 (S) - camptothecin analog | RESEARCH TRIANGLE INSTITUTE (US) | 1991-03-20 | — | — | EP | disclosed |