Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9123318 | 0.85 | MAPT (0.52) | HIF1AEPAS1TP53CYP3A4KDM4E | |
| SCHEMBL21647668 | 0.83 | HIF1A (0.42) | HIF1AEPAS1TP53CYP3A4KDM4E | |
| SCHEMBL70459 | 0.83 | ESR1 (0.49) | HIF1AEPAS1TP53CYP3A4KDM4E | |
| SCHEMBL9275892 | 0.81 | ALDH1A1 (0.43) | HIF1AEPAS1TP53CYP3A4KDM4E | |
| SCHEMBL1608046 | 0.81 | ALDH1A1 (0.54) | HIF1AEPAS1TP53CYP3A4KDM4E | |
| Hydrochloric Acid SCHEMBL11424028 | 0.81 | ESR1 (0.47) | HIF1AEPAS1TP53CYP3A4KDM4E | |
| SCHEMBL9742294 | 0.80 | KDM4E (0.65) | HIF1AEPAS1TP53CYP3A4KDM4E | |
| SCHEMBL5141870 | 0.79 | MAOB (0.45) | HIF1AEPAS1TP53CYP3A4KDM4E | |
| Hydrochloric Acid SCHEMBL28767777 | 0.79 | ESR1 (0.46) | HIF1AEPAS1TP53CYP3A4KDM4E | |
| SCHEMBL29421917 | 0.79 | MAOB (0.45) | HIF1AEPAS1TP53CYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010131191-A1 | THIAZOLIDIN-4-ONE AND [1,3]-THIAZINAN-4-ONE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-11-18 | — | — | WO | disclosed |
| WO-2010131192-A2 | NOVEL OXAZOLIDINONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-11-18 | — | — | WO | disclosed |