Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 5/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 4/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL814000 | 0.82 | KMT2A (0.46) | HSD17B10ESR1HIF1ARECQLKMT2A | |
| SCHEMBL4641891 | 0.82 | HSD17B10 (0.43) | HSD17B10THRBKMT2AALOX15ALOX12 | |
| SCHEMBL4021940 | 0.80 | THRA (0.44) | HSD17B10THRBRECQLKMT2ASMN1; SMN2 | |
| SCHEMBL4642204 | 0.80 | HSD17B10 (0.42) | HSD17B10THRBKMT2AALOX15ALOX12 | |
| SCHEMBL4641747 | 0.80 | HSD17B10 (0.42) | HSD17B10THRBESR1KMT2AALOX15 | |
| SCHEMBL4646760 | 0.78 | HSD17B10 (0.41) | HSD17B10THRBESR1KMT2AALOX15 | |
| SCHEMBL9169212 | 0.78 | HSD17B10 (0.41) | HSD17B10THRBKMT2AALOX15THRA | |
| SCHEMBL14142981 | 0.78 | HSD17B10 (0.41) | HSD17B10THRBKMT2ASMN1; SMN2ALOX15 | |
| SCHEMBL29131729 | 0.78 | KMT2A (0.48) | HSD17B10ESR1HIF1ARECQLKMT2A | |
| SCHEMBL4647871 | 0.77 | HSD17B10 (0.40) | HSD17B10THRBESR1KMT2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11160773-B2 | Method for enhancing folding and transport of misfolded glucocerebrosidase | THE HOSPITAL FOR SICK CHILDREN (CA) | 2021-11-02 | — | — | US | disclosed |
| US-20200246282-A1 | Method for Enhancing Folding and Transport of Misfolded Glucocerebrosidase | THE HOSPITAL FOR SICK CHILDREN (CA) | 2020-08-06 | — | — | US | disclosed |
| US-10653645-B2 | Method for enhancing folding and transport of misfolded glucocerebrosidase | THE HOSPITAL FOR SICK CHILDREN (CA) | 2020-05-19 | — | — | US | disclosed |
| US-10028922-B2 | Method for enhancing folding and transport of misfolded glucocerebrosidase | THE HOSPITAL FOR SICK CHILDREN (CA) | 2018-07-24 | — | — | US | disclosed |
| US-10028922-B2 | Method for enhancing folding and transport of misfolded glucocerebrosidase | THE HOSPITAL FOR SICK CHILDREN (CA) | 2018-07-24 | — | — | US | disclosed |
| US-20160331701-A1 | Method for Enhancing Folding and Transport of Misfolded Glucocerebrosidase | MCMASTER UNIVERSITY (CA) | 2016-11-17 | — | — | US | disclosed |
| US-20160331701-A1 | Method for Enhancing Folding and Transport of Misfolded Glucocerebrosidase | MCMASTER UNIVERSITY (CA) | 2016-11-17 | — | — | US | disclosed |
| US-9415025-B2 | Methods of treating Parkinson's disease | THE HOSPITAL FOR SICK CHILDREN (CA) | 2016-08-16 | — | — | US | disclosed |
| US-9415025-B2 | Methods of treating Parkinson's disease | THE HOSPITAL FOR SICK CHILDREN (CA) | 2016-08-16 | — | — | US | disclosed |
| US-20160113892-A1 | Method For Enhancing Folding and Transport of Misfolded Glucocerebrosidase | MCMASTER UNIVERSITY (CA) | 2016-04-28 | — | — | US | disclosed |
| US-20130184352-A1 | METHOD OF TREATING GAUCHER DISEASE | MCMASTER UNIVERSITY (CA) | 2013-07-18 | — | — | US | disclosed |
| US-20130090388-A1 | METHOD OF TREATING GAUCHER DISEASE | MCMASTER UNIVERSITY (CA) | 2013-04-11 | — | — | US | disclosed |
| US-20130090388-A1 | METHOD OF TREATING GAUCHER DISEASE | MCMASTER UNIVERSITY (CA) | 2013-04-11 | — | — | US | disclosed |
| US-8124597-B2 | Method of treating gaucher disease | THE HOSPITAL FOR SICK CHILDREN (CA) | 2012-02-28 | — | — | US | disclosed |
| US-8124597-B2 | Method of treating gaucher disease | THE HOSPITAL FOR SICK CHILDREN (CA) | 2012-02-28 | — | — | US | disclosed |
| US-20120021487-A1 | METHOD OF TREATING GAUCHER DISEASE | MCMASTER UNIVERSITY (CA) | 2012-01-26 | — | — | US | disclosed |
| US-20120021487-A1 | METHOD OF TREATING GAUCHER DISEASE | MCMASTER UNIVERSITY (CA) | 2012-01-26 | — | — | US | disclosed |
| WO-2009038695-A1 | METHOD OF TREATING GAUCHER DISEASE | THE HOSPITAL FOR SICK CHILDREN (CA) | 2009-03-26 | — | — | WO | disclosed |
| US-20090075960-A1 | Method of treating gaucher disease | THE HOSPITAL FOR SICK CHILDREN (CA) | 2009-03-19 | — | — | US | disclosed |
| US-20090075960-A1 | Method of treating gaucher disease | THE HOSPITAL FOR SICK CHILDREN (CA) | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090075960-A1 | Method of treating gaucher disease | GBA1, GAA, GBA3 | HSD17B10 791/4885THRB 2527/4885ESR1 4877/4885 |
| US-20200246282-A1 | Method for Enhancing Folding and Transport of Misfolded Glucocerebrosidase | GBA1, GBA3, GAA | HSD17B10 1082/4885THRB 3414/4885ESR1 4877/4885 |
| US-10653645-B2 | Method for enhancing folding and transport of misfolded glucocerebrosidase | GBA1, GBA3, GAA | HSD17B10 1082/4885THRB 3414/4885ESR1 4877/4885 |
| US-11160773-B2 | Method for enhancing folding and transport of misfolded glucocerebrosidase | GBA1, GBA3, GAA | HSD17B10 1082/4885THRB 3414/4885ESR1 4877/4885 |
| US-20160113892-A1 | Method For Enhancing Folding and Transport of Misfolded Glucocerebrosidase | GBA1, GBA3, GAA | HSD17B10 1082/4885THRB 3414/4885ESR1 4877/4885 |
| US-20130090388-A1 | METHOD OF TREATING GAUCHER DISEASE | GBA1, GAA, GBA3 | HSD17B10 791/4885THRB 2527/4885ESR1 4877/4885 |
| US-20160331701-A1 | Method for Enhancing Folding and Transport of Misfolded Glucocerebrosidase | GBA1, GBA3, GAA | HSD17B10 1082/4885THRB 3414/4885ESR1 4877/4885 |
| US-10028922-B2 | Method for enhancing folding and transport of misfolded glucocerebrosidase | GBA1, GBA3, GAA | HSD17B10 1082/4885THRB 3414/4885ESR1 4877/4885 |
| US-20130184352-A1 | METHOD OF TREATING GAUCHER DISEASE | GBA1, GAA, GBA3 | HSD17B10 791/4885THRB 2527/4885ESR1 4877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.