Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SENP1 | Q9P0U3 | 2/20 | 0.48 |
| ▸ | CASR | P41180 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7861967 | 0.89 | NAMPT (0.54) | MAPK1LMNAALDH1A1HPGDHTT | |
| SCHEMBL7861969 | 0.83 | MAPK1 (0.52) | MAPK1LMNAALDH1A1HPGDHTT | |
| SCHEMBL7864788 | 0.83 | SIRT2 (0.44) | MAPK1LMNAALDH1A1HPGDHTT | |
| SCHEMBL7856448 | 0.81 | PPARG (0.68) | MAPK1LMNAALDH1A1HPGDHTT | |
| SCHEMBL7372565 | 0.79 | ITGB3 (0.62) | MAPK1ALDH1A1KDRL3MBTL1RAB9A | |
| SCHEMBL7864758 | 0.79 | KMT2A (0.47) | LMNAALDH1A1KMT2ASIRT2MAPT | |
| SCHEMBL8440655 | 0.79 | MAPK1 (0.55) | MAPK1LMNAALDH1A1HPGDHTT | |
| SCHEMBL7864272 | 0.78 | NAMPT (0.58) | — | |
| SCHEMBL7803055 | 0.78 | KDR (0.58) | MAPK1LMNAALDH1A1HPGDHTT | |
| SCHEMBL7833496 | 0.77 | ITGB3 (0.58) | MAPK1LMNAALDH1A1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | claimed |