Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NOS3 | P29474 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 1/20 | 0.45 |
| ▸ | NOS2 | P35228 | 1/20 | 0.45 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7866954 | 0.93 | KMT2A (0.47) | KMT2AKCNK3KCNK9NR1H4ALDH1A1 | |
| SCHEMBL7856443 | 0.85 | LMNA (0.45) | KMT2AKCNK9NR1H4ALDH1A1LMNA | |
| SCHEMBL7856532 | 0.80 | CA1 (0.51) | KMT2AALDH1A1LMNAMAPTNOS3 | |
| SCHEMBL7862052 | 0.79 | MAPK1 (0.52) | KMT2AALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL7856232 | 0.77 | KCNK3 (0.50) | KMT2AKCNK3KCNK9SIRT1MAPT | |
| SCHEMBL7378809 | 0.76 | NR1H4 (0.50) | KMT2ANR1H4ALDH1A1MEN1ITGB3 | |
| SCHEMBL10869967 | 0.76 | ALDH1A1 (0.60) | KMT2AALDH1A1EPHX1SMN1; SMN2POLB | |
| SCHEMBL8500048 | 0.75 | LMNA (0.50) | KMT2AALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL7739117 | 0.75 | KCNK3 (0.82) | KMT2AKCNK3KCNK9ALDH1A1SIRT1 | |
| SCHEMBL2839379 | 0.73 | MAPK1 (0.55) | KMT2AKCNK3KCNK9NR1H4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-B1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | SEARLE & CO (US) | 2001-08-29 | — | — | EP | claimed |