Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.51 |
| ▸ | RAB9A | P51151 | 8/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.44 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7867703 | 0.93 | EGFR (0.45) | NPC1RAB9ASMN1; SMN2HPGDP4HTM | |
| SCHEMBL7871544 | 0.91 | MCL1 (0.49) | BCL2L1MCL1P4HTM | |
| SCHEMBL7874619 | 0.91 | HPGD (0.47) | NPC1RAB9ASMN1; SMN2HPGDP4HTM | |
| SCHEMBL7867895 | 0.90 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL9574842 | 0.90 | EGFR (0.43) | NPC1RAB9ASMN1; SMN2HPGDP4HTM | |
| SCHEMBL7869460 | 0.90 | EGFR (0.43) | NPC1RAB9ASMN1; SMN2HPGDP4HTM | |
| SCHEMBL7871550 | 0.90 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL7874534 | 0.89 | EGFR (0.42) | NPC1RAB9ASMN1; SMN2HPGDP4HTM | |
| SCHEMBL7862692 | 0.89 | EGFR (0.43) | NPC1RAB9ASMN1; SMN2HPGDP4HTM | |
| SCHEMBL9574776 | 0.89 | ALDH1A1 (0.44) | NPC1RAB9ASMN1; SMN2HPGDP4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562512-B1 | Sulfonamidocarbonylpyridine-2-carboxamides and their use as medicines | HOECHST AG (DE) | 2001-02-21 | — | — | EP | disclosed |
| EP-0562512-A1 | Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-09-29 | — | — | EP | disclosed |