Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7571757 | 0.86 | MEN1 (0.53) | MEN1KMT2AL3MBTL1POLBALDH1A1 | |
| SCHEMBL7455062 | 0.80 | SMN1; SMN2 (0.55) | MEN1KMT2ALMNAP2RX7SMN1; SMN2 | |
| SCHEMBL8081036 | 0.76 | P2RX7 (0.52) | LMNAP2RX7THRB | |
| SCHEMBL7864022 | 0.75 | P2RX7 (0.46) | MEN1KMT2AALDH1A1P2RX7CNR2 | |
| SCHEMBL11604066 | 0.71 | KMT2A (0.60) | MEN1KMT2AL3MBTL1POLBALDH1A1 | |
| SCHEMBL8071740 | 0.69 | NPC1 (0.53) | MEN1KMT2AL3MBTL1POLBALDH1A1 | |
| SCHEMBL11326653 | 0.68 | KMT2A (0.60) | MEN1KMT2AL3MBTL1POLBALDH1A1 | |
| SCHEMBL11829901 | 0.68 | KMT2A (0.51) | MEN1KMT2AL3MBTL1POLBALDH1A1 | |
| SCHEMBL7517360 | 0.68 | P2RX7 (0.72) | P2RX7 | |
| SCHEMBL7690936 | 0.67 | P2RX7 (0.73) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303659-B2 | Compounds | ASTRAZENECA AB (SE) | 2001-10-16 | — | — | US | disclosed |
| EP-1036059-A1 | ADAMANTANE DERIVATIVES | AstraZeneca UK Limited (GB) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029661-A1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |